An Extensible User Interface for Lean 4

Contemporary proof assistants rely on complex automation and process libraries with millions of lines of code. At these scales, understanding the emergent interactions between components can be a serious challenge. One way of managing complexity, long established in informal practice, is through varying external representations. For instance, algebraic notation facilitates term-based reasoning whereas geometric diagrams invoke spatial intuition. Objects viewed one way become much simpler than when viewed differently. In contrast, modern general-purpose ITP systems usually only support limited, textual representations. Treating this as a problem of human-computer interaction, we aim to demonstrate that presentations - UI elements that store references to the objects they are displaying - are a fruitful way of thinking about ITP interface design. They allow us to make headway on two fronts - introspection of prover internals and support for diagrammatic reasoning. To this end we have built an extensible user interface for the Lean 4 prover with an associated ProofWidgets 4 library of presentation-based UI components. We demonstrate the system with several examples including type information popups, structured traces, contextual suggestions, a display for algebraic reasoning, and visualizations of red-black trees. Our interface is already part of the core Lean distribution

Crucible of the Civil War: Virginia from Secession to Commemoration

Crucible of the Civil War offers an illuminating portrait of the state’s wartime economic, political, and social institutions. Weighing in on contentious issues within established scholarship while also breaking ground in areas long neglected by scholars, the contributors examine such concerns as the war’s effect on slavery in the state, the wartime intersection of race and religion, and the development of Confederate social networks. They also shed light on topics long disputed by historians, such as Virginia’s decision to secede from the Union, the development of Confederate nationalism, and how Virginians chose to remember the war after its close.https://scholarship.richmond.edu/bookshelf/1258/thumbnail.jp

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice